Reference:
Wu G, Wang D, Roswell L, et al. The effect of acute exposure to morphine on breathing variability and cardiopulmonary coupling in men with obstructive sleep apnea – and RTC Study. J Sleep Res 2019. DOI: 10.1111/jsr.12930
Objectives:
Opioid-related deaths from respiratory depression are increasing but there is only limited information on the effect of morphine on breathing during sleep. This study aimed to detect and quantify opioid-induced cardiorespiratory pattern changes during sleep in obstructive sleep apnea (OSA) patients using novel automated methods and correlate these with conventional polysomnography (PSG) measures.
Conclusions:
A higher CPC sleep quality index (SQI) was found with morphine use. The change of key Inter-breath interval (IBI) and Cardiopulmonary Coupling (CPC) techniques and a range of Polysomnography (PSG) sleep-disordered breathing parameters may suggest a practical value as surrogate overnight cardiorespiratory measurements, because both respiratory flow and ECG can be detected by smell portable devices.
Practical Significance:
The change of key Inter-breath interval (IBI) and Cardiopulmonary Coupling (CPC) techniques and a range of Polysomnography (PSG) sleep-disordered breathing parameters may suggest a practical value as surrogate overnight cardiorespiratory measurements, because both respiratory flow and ECG can be detected by small portable devices.