The Effect of Acute Exposure to Morphine on Breathing Variability and Cardiopulmonary Coupling in Men with Obstructive sleep apnea – a randomized controlled trial

Reference:
Wu G, Wang D, Roswell L, et al. The effect of acute exposure to morphine on breathing variability and cardiopulmonary coupling in men with obstructive sleep apnea – and RTC Study. J Sleep Res 2019. DOI: 10.1111/jsr.12930

Objectives:
Opioid-related deaths from respiratory depression are increasing but there is only limited information on the effect of morphine on breathing during sleep. This study aimed to detect and quantify opioid-induced cardiorespiratory pattern changes during sleep in obstructive sleep apnea (OSA) patients using novel automated methods and correlate these with conventional polysomnography (PSG) measures.

Conclusions:
A higher CPC sleep quality index (SQI) was found with morphine use. The change of key Inter-breath interval (IBI) and Cardiopulmonary Coupling (CPC) techniques and a range of Polysomnography (PSG) sleep-disordered breathing parameters may suggest a practical value as surrogate overnight cardiorespiratory measurements, because both respiratory flow and ECG can be detected by smell portable devices.

Practical Significance:

The change of key Inter-breath interval (IBI) and Cardiopulmonary Coupling (CPC) techniques and a range of Polysomnography (PSG) sleep-disordered breathing parameters may suggest a practical value as surrogate overnight cardiorespiratory measurements, because both respiratory flow and ECG can be detected by small portable devices.

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The Effect of Acute Exposure to Morphine on Breathing Variability and Cardiopulmonary Coupling in Men with Obstructive sleep apnea – a randomized controlled trial