Sleep Quality, Sleep Apnea and Metabolic Health in Children Treated with Adenotonsillectomy

Reference:

Magnusdottir S, Witmans M, Hilmisson H. Sleep quality, sleep apnea, and metabolic health in children treated with adenotonsillectomy. DOI: 10.1007/s11325-022-02747-3

Objective:

To evaluate if cardiopulmonary coupling (CPC) calculated sleep quality (SQI) may predict changes in metabolic health in children treated with early adenotonsillectomy (eAT) for Obstructive Sleep Apnea (OSA).

Conclusion:

Children with moderate-severe OSA and lower-SQI (Group2) increased their BMI-z score less than children with mild-OSA and higher-SQI (Group1) 0.13 vs. 0.27 (p=0.025) after surgery, improved their (p=0.025), improved their SQI +2.06 compared to decline -3.75 in Group1, (p=0.015), decreased AHRSleep -2.90 vs. -0.34 (p=0.025) and AHI -5.00 vs. -0.36 (p=0.002).

Children that had remission of their OSA and high-SQI after surgery (GropupRemission) was younger 6.59 vs. 7.41; p<0.001; with lower BMI z-score 0.90 vs. 1.34;p=0.021; AHRSleep 80.60 vs. 83.50;p=0.032; fasting insulin (µIU/ml) 7.54 vs. 12.58;p=0.017 and glucose (mmol/L) 4.45 vs. 4.60;p=0.049, with better lipid metabolism though not significantly, low-density-lipoprotein 90.26 mg/dL vs. 97.94;p=0.081 and cholesterol 154.66 mg/dL vs. 164.36;p=0.076 compared to the children with OSA (AHI>1) and lower-SQI at 7-month follow-up.

Practical Significance:

The results may indicate that children with mild-OSA and high-SQI may be less likely to benefit from eAT than children with moderate-OSA. To improve metabolic health, successfully treating both AHI and SQI is likely needed. CPC-calculated SQI may have a role to identify children less likely to benefit from eAT and to evaluate success of therapy.

View Publication

Sleep Quality, Sleep Apnea and Metabolic Health in Children Treated with Adenotonsillectomy

Reference:

Magnusdottir S, Witmans M, Hilmisson H. Sleep quality, sleep apnea, and metabolic health in children treated with adenotonsillectomy. DOI: 10.1007/s11325-022-02747-3

Objective:

To evaluate if cardiopulmonary coupling (CPC) calculated sleep quality (SQI) may predict changes in metabolic health in children treated with early adenotonsillectomy (eAT) for Obstructive Sleep Apnea (OSA).

Conclusion:

Children with moderate-severe OSA and lower-SQI (Group2) increased their BMI-z score less than children with mild-OSA and higher-SQI (Group1) 0.13 vs. 0.27 (p=0.025) after surgery, improved their (p=0.025), improved their SQI +2.06 compared to decline -3.75 in Group1, (p=0.015), decreased AHRSleep -2.90 vs. -0.34 (p=0.025) and AHI -5.00 vs. -0.36 (p=0.002).

Children that had remission of their OSA and high-SQI after surgery (GropupRemission) was younger 6.59 vs. 7.41; p<0.001; with lower BMI z-score 0.90 vs. 1.34;p=0.021; AHRSleep 80.60 vs. 83.50;p=0.032; fasting insulin (µIU/ml) 7.54 vs. 12.58;p=0.017 and glucose (mmol/L) 4.45 vs. 4.60;p=0.049, with better lipid metabolism though not significantly, low-density-lipoprotein 90.26 mg/dL vs. 97.94;p=0.081 and cholesterol 154.66 mg/dL vs. 164.36;p=0.076 compared to the children with OSA (AHI>1) and lower-SQI at 7-month follow-up.

Practical Significance:

The results may indicate that children with mild-OSA and high-SQI may be less likely to benefit from eAT than children with moderate-OSA. To improve metabolic health, successfully treating both AHI and SQI is likely needed. CPC-calculated SQI may have a role to identify children less likely to benefit from eAT and to evaluate success of therapy.

View Publication