Sleep Disordered Breathing assessed by Holter-monitoring is associated to worsened one-year clinical outcomes in ischemic stroke patients: A Cardiopulmonary Coupling analysis

Reference:
Na J, Kang D, Kim C, Park Y, Jang W, Kim W, Choi C. Sleep Disordered Breathing assessed by Holter-monitoring is associated to worsened one-year clinical outcomes in ischemic stroke patients: A Cardiopulmonary Coupling Analysis. Sleep Medicine 2019. DOI: 10.1016/j.sleep.2019.11.756

Objectives:
Sleep-disorder breathing (SDB) using polysomnography is closely associated to poor functional and clinical outcomes in ischemic stroke patients. The cardiopulmonary coupling analysis using Holter-monitoring (CPC-Holter analysis) is an emerging feasible modality to investigate SDB. We investigated the association between SDB defined by CPC-Holter analysis and one-year clinical outcome in patients with acute ischemic stroke.

Conclusions:
Patients with increased CPC- marker of periodicity (eLFCNB) showed significantly higher incidence of both recurrent ischemic stroke (8.3% vs. 1.4%, p<0.001) and major cerebrovascular event (JACE), a composite of recurrent ischemic stroke, transient ischemic attack and all-cause mortality within one year since discharge. SDB assessed by CPC-Holter analysis at early phase of ischemic stroke is a powerful prognostic marker for predicting one-year adverse clinical outcomes.

Practical Significance:
The CPC-analysis can be useful and easily assessable modality for predicting clinical outcomes in acute ischemic stroke.

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Sleep Disordered Breathing assessed by Holter-monitoring is associated to worsened one-year clinical outcomes in ischemic stroke patients: A Cardiopulmonary Coupling analysis