Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review

Reference:
Jackson ML; Bruck D. Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review. J Clin Sleep Med 2012;8(6):719-728. DOI: 10.5664/jcsm.2276 

Objectives:
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a medically unexplained disabling illness, with prevalence estimates of between 0.007% and 2.8% of the general adult population. It is primarily characterized by persistent relapsing fatigue of at least 6 months in duration that reduces activity levels. The current review aims to provide a comprehensive overview of these studies, describe where the field currently stands on this issue, and outline potential directions for future research.

Conclusions:
There is preliminary evidence that sleep quality and stability measured by CPC is poor in CFS/ME patients, with reduced high-frequency coupling and increased low-frequency coupling.

Practical Significance:
Studies utilizing such autonomic activity techniques indicate that autonomic measures during sleep may be a promising mechanism associated with non-restorative sleep in CFS/ME.

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Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review