Jackson ML; Bruck D. Sleep abnormalities in chronic fatigue syndrome/myalgic encephalomyelitis: a review. J Clin Sleep Med 2012;8(6):719-728. DOI: 10.5664/jcsm.2276
Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a medically unexplained disabling illness, with prevalence estimates of between 0.007% and 2.8% of the general adult population. It is primarily characterized by persistent relapsing fatigue of at least 6 months in duration that reduces activity levels. The current review aims to provide a comprehensive overview of these studies, describe where the field currently stands on this issue, and outline potential directions for future research.
There is preliminary evidence that sleep quality and stability measured by CPC is poor in CFS/ME patients, with reduced high-frequency coupling and increased low-frequency coupling.
Studies utilizing such autonomic activity techniques indicate that autonomic measures during sleep may be a promising mechanism associated with non-restorative sleep in CFS/ME.