Ibrahim LH, Jacono FJ, Patel SR, et al. Heritability of abnormalities in cardiopulmonary coupling in sleep apnea: use of an electrocardiogram-based technique. Sleep 2010; 33 (5): 643-46. PMID: 20469806 PMCID: PMC2864879
To evaluate the familial aggregation of distinctive spectrographic biomarkers of unstable sleep, related to elevated-low frequency (e-LFC), and to assess their utility in genetic studies.
Approximately 30% of the variability of e-LFC, measured from a continuous ECG during sleep is explained by familial factors other than BMI. ECG-based spectrographic measures of heart rate variability & breathing rate may provide novel markers for characterizing subgroups of individuals with different propensities and genetic etiologies for sleep apnea or for other conditions associated with sleep fragmentation.
This study suggests that CPC provides an objective measure aimed to enhance our understanding of the genetics of OSA by identifying intermediate traits with high heritability.