ECG-based cardiopulmonary coupling for sleep stability assessment in patients with amyotrophic lateral sclerosis

Reference:
S. Mariani, P. Congiu, G. Milioli, G. Gioi, G. Borghero, F. Marrosu, R.J. Thomas, A.L. Goldberger, M. Puligheddu. ECG-based cardiopulmonary coupling for sleep stability assessment in patients with amyotrophic lateral sclerosis. Mov Disord 2016; 31 (suppl 2). http://www.mdsabstracts.org/abstract/ecg- based-cardiopulmonary-coupling-for-sleep-stability-assessment-in-patients-with-amyotrophic-lateral-sclerosis/

Objectives:
The goal of this preliminary study is to introduce the technique of CardioPulmonary Coupling (CPC) to visualize and quantify the sleep spectrograms of Amyotrophic Lateral Sclerosis (ALS) patients with different ages and pathology severity and estimate the percentage of stable sleep and unstable sleep during the night.

Conclusions:
Subjects with the most advanced pathology had the most unstable sleep patterns.

Practical Significance:
ALS is a progressive neurodegenerative disease. Sleep quality and fragmentation in ALS patients have not yet been extensively studied. Electrocardiogram (ECG)-based (CPC) provides a graphical and computational method to represent the behavior of dynamical interactions between the cardio-autonomics and respiration during sleep.

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ECG-based cardiopulmonary coupling for sleep stability assessment in patients with amyotrophic lateral sclerosis