Cardiopulmonary coupling spectrogram as an ambulatory clinical biomarker of sleep stability and quality in health, sleep apnea, and insomnia

Reference:
Thomas RJ, Wood C, Bianchi M. Cardiopulmonary Coupling spectrogram as an ambulatory clinical biomarker of sleep stability and quality in health, sleep apnea and insomnia. Sleep 2018; 41(2):1-11. DOI:10.1093/sleep/zsx196

Objectives:
The objective was to evaluate a wearable device which used novel computational analysis of the electrocardiogram (ECG), collected over multiple nights, as a method to track the dynamics of sleep quality in health and disease, the  Cardiopulmonary coupling spectrogram,  as an ambulatory clinical biomarker of sleep stability and quality in health, sleep apnea and insomnia.

Conclusions:
The CardioPulmonary coupling (CPC) method provides new opportunities to measure sleep in dynamic ways not possible before. These measurements can yield new biological insights and aid clinical management.

Practical Significance:
The SleepImage system demonstrates clinically useful characteristics which can be applied to sleep medicine practice. Tracking the dynamics of sleep over prolonged periods of time is likely to provide unique insights into sleep regulation in health and disease.

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Cardiopulmonary coupling spectrogram as an ambulatory clinical biomarker of sleep stability and quality in health, sleep apnea, and insomnia