Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk

Reference:
Schramm PJ, Polland RE, Rao U et al. Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk. Eur Neuropsychopharmacol 2014; 24(2): 207-14. DOI: 10.1016/j.euroneuro.2013.09.007

Objectives:
To evaluate bupropion response in depressed patients by polysomnography (PSG) and cardiopulmonary coupling (CPC) variables.

Conclusions:
The present study found complimentary results between PSG and CPC measured. Bupropion increased REM latency but did not impact PSG sleep continuity, architecture and CPC variables. 

Practical Significance:
These findings have important implications for clinical treatment of depression and whether the beneficial effects of antidepressant medication outweighs the impact on cardiopulmonary benefits. 

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Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk