Schramm PJ, Polland RE, Rao U et al. Bupropion response on sleep quality in patients with depression: implications for increased cardiovascular disease risk. Eur Neuropsychopharmacol 2014; 24(2): 207-14. DOI: 10.1016/j.euroneuro.2013.09.007
To evaluate bupropion response in depressed patients by polysomnography (PSG) and cardiopulmonary coupling (CPC) variables.
The present study found complimentary results between PSG and CPC measured. Bupropion increased REM latency but did not impact PSG sleep continuity, architecture and CPC variables.
These findings have important implications for clinical treatment of depression and whether the beneficial effects of antidepressant medication outweighs the impact on cardiopulmonary benefits.