Pawar R, Hilmisson H, Crawford B, Thomas R, Blattner M. Characterization of Sleep Quality in Patients with Idiopathic Hypersomnia using Cardiopulmonary Coupling. Sleep 2022; 45 (supplement_1). DOI: 10.1093/sleep/zsac079.416
Idiopathic Hypersomnia (IH) is characterized clinically be excessive daytime sleepiness, prolonged or unrefreshing sleep and sleep inertia. The ICSD-3 classifies IH as having expected proportions of NREM and REM sleep, normal REM latency and relatively high sleep efficiency. However, there is limited data on sleep quality in these patients and whether this disease state comprises of patients with a homogenous spectrum of sleep quality.
Two sleep quality groups were identified, group with higher-SQI (>55) with mean SQI 71.5 and group with lower-SQI (<55) with mean SQI 38.5, p<0.001. The SQI was not predicted by AHI<10, age, gender, or total sleep time.
Two clusters were identified in IH. Patients with adequate SQI have more refreshed sleep. This may suggest that possibly different phenotypes and endotypes exist that may impact treatment responses.